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How Does Our Prohormone Supplement Work


In this article, we are going though how does our Prohormone Supplement (Series) perform and we are going to use our product "4-Androgin" as an example for comparing with traditional testosterone booster. To express our honesty and effectiveness of our products, we are using the scientific research papers in the field of medicine as reference and support since they include extended experimental tests and results in human. We all agree that published scientific journals are the most reliable and convincing source instead of non data-driven product reviews written by non scientists/YouTubers/Unknown bloggers.

What is total testosterone, bioavailable testosterone and bound testosterone?

Figure 1. The concept of total testosterone, bioavailable testosterone and bound testosterone[1]

A "total" testosterone lab test measures free testosterone as well as the amount of hormone bound to the proteins albumin and sex hormone binding globulin (SHBG). Free and albumin-bound hormone are "bioavailable" and thus active in the body. Testosterone and dihydrotestosterone (DHT) circulate in plasma unbound with only 2-3% content level in averaged healthy persons.[1]

Bioavailable testosterone is a strongest impact on body building composition.

Non-SHBG-Testosterone and calculated-Free Testosterone are more strongly related to muscle strength, bone mineral density (BMD), and fat mass than Total Testosterone (TT). They are also significantly related to hip BMD. [2]

Is oral testosterone booster products help with bioavailable testosterone in order to get more lean muscles?

Yes! But unfortunately, not in an effective way.

An experimental study was carried out by Department of Medicine at University of Adelaide. 76 healthy men were treated for 12 months with testosterone undecanoate. Their blood samples were then analyzed and their mean percentage change of free testosterone versus time plot were obtained as following figure 2:[3]


free testosterone vs time by taking testosterone booster
Figure 2. Total testosterone (Total T), sex hormone binding globulin (SHBG), free testosterone index (FTI), and calculated bioavailable testosterone (cBT) respectively vs time by taking testosterone booster for 12 months [3]

This interesting experimental study shows that our body fails to maintain the bioavailable testosterone level at the high and optimum level after 1st month by taking oral testosterone supplements. Eventually, its level start to fall back to the equilibrium level with a plateau region. Note that the percentage change of bioavailable testosterone was roughly staying at +30% at the equilibrium.

Is our Prohormone products help with bioavailable testosterone to get more lean muscles?

Let's take a look at the another experimental study published in The Journal of Clinical Endocrinology & Metabolism [5]. 9 healthy men were treated with 4-Androstenedione, which is one of the 1st step metabolite of our 4-Androgin product. The final metabolic conversion will be testosterone as shown in the following figure 3 from research study published in the Journal of Medicine & Science in Sports & Exercise: [4]

Interconversions of testosterone precursors
Figure 3. A map of interconversion of testosterone precursors [4]

The total Androstenedione, total testosterone and free testosterone level of 9 healthy men who were treated with 4-Androstenedione at their week 12 was summarized in the following figure: [5]

Free testosterone level by taking 4-androgin
Figure 4 (A). Total Androstenedione, (B). Total testosterone and (C). Free testosterone level of 9 healthy men vs time by taking 4-Androstenedione for 3 months [5]

At figure 4(C), the percentage change of free testosterone content is over 100% at the end of their 3rd months.

We want to conclude that 4-Androgin is at least 6 times more potent than traditional testosterone booster products. Also, 4-Androgin can convert to DHT, which is 5 times more potent than testosterone. We hardly know how effective is 4-Androgin than traditional testosterone booster. We definitely need more researchers to conduct the ongoing studies.

Mega Muscles™

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